The length of DNA in each cell is ~ 1 meter. A person has 1014 cells. The length of DNA in a single person:~1014 m Distance to moon is ~108 m, to the sun ~1011 m and to nearest star ~1016 m
Probably the most famous sentence in science: “It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material"
Please note that there are no small men who put the parts together, it happens all by random diffusion. It is a self organizing system
Double stranded DNA from a small virus.
Individual molecules are not visible, and the double helix appears as a long thread
DNA lesion occurs at a rate of 1,000 to 1,000,000 molecular lesions per cell per day. This constitutes only 0.000165% but must be dealt with
Thus just cell division can cause cancer, no special cause is necessary
p53 is an attractive therapeutic target in oncology because its tumour-suppressor activity can be stimulated to eradicate tumour cells. Inhibiting the p53?MDM2 interaction is a promising approach for activating p53, because this association is well characterized at the structural and biological levels. MDM2 inhibits p53 transcriptional activity, favours its nuclear export and stimulates its degradation, so inhibiting the p53?MDM2 interaction with synthetic molecules should lead to p53-mediated cell-cycle arrest or apoptosis in p53-positive stressed cells.
HRD 콘텐츠
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